ULTRAPLACAD

ULTRAsensitive PLAsmonic devices for early CAncer Diagnosis

Cancer biomarkers circulating in body fluids have been shown to reflect the pathological process and for this reason can be used for cancer diagnosis, prognosis and choice for therapeutic interventions. It is proven that their detection is a key to new minimal-invasive detection approaches. However, barriers to wide spread use of similar approaches are lack of test sensitivity, specificity and limited availability of low cost detection platforms. This project is focused at developing a compact plasmonic-based device with integrated microfluidic circuit and functionalized nanostructures for the detection of DNA, microRNA and tumor autoantibodies cancer biomarkers. The aim is to detect cancer biomarkers circulating in blood with improvement in sensitivity of factor up to 1000, reduction in cost of platform of factor ranging from 2 to 4 compared to today’s available techniques and analysis time less than 60 minutes. The proposed detection approach will provide ultrasensitive detection of biomolecular systems with no need for complex sample chemical modifications thus allowing direct and simple assays to be performed. Within the project a bimodal industrial prototype will be developed integrating novel surface plasmon resonance imaging and plasmon enhanced fluorescence sensing technologies, respectively. Automated fabrication processes suitable for low cost mass production will be developed and applied to produce disposable integrated chips. Prototype will be specifically fabricated for early diagnosis and prognosis of colorectal cancer. The team includes partners holding cross-disciplinary competencies needed to achieve the proposed results, including two of the first five plasmon resonance groups in the world, the inventor of surface plasmon microscopy – also known as surface plasmon resonance imaging- and plasmon-enhanced fluorescence spectroscopy, and full European value chain including disposable chip and readout platforms design, development and manufacturing.

AMIRES was involved in the proposal preparation and in the project’s preparatory phase. Within the project it is responsible for administrative and financial project management. AMIRES will support coordination of project meetings (including External Advisory Board meetings), dissemination (e.g. webpage, press releases, leaflets, clustering activities) and exploitation (enlarge the impact of the developed know-how, support to companies and provide liaison with other SMEs and industries).

• Project partners:
  • National Institute of Biostructures and Biosystems (INBB), Italy
  • Austrian Institute of Technology (AIT), Austria
  • Institute of Photonics and Electronics (IPE),  Czech Republic
  • Italian National Cancer Institute Regina Elena (IRE), Italy
  • University of Twente (UT), Netherlands
  • University of Siegen, (USIEGEN), Germany
  • University of Ferrara (UFE), Italy
  • VTT Technical Research Centre of Finland (VTT), Finland
  • Scriba Nanotecnologie (SCRIBA), Italy
  • Ginolis Oy (GIN), Finland
  • Future Diagnostics Solutions (FDx), Netherlands
  • Horiba Jobin Yvon SAS (HJY), France
  • AMIRES S.R.O., Czech Republic

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 633937, project ULTRAPLACAD.